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NOIR-375


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Description

COMPOSITION: – AMOXYCILLIN TRIHYDRATE 250 MG+ CLAVULANIC ACID 125 MG

PACKING: – 10X1X10

M.R.P: – 1500

Amoxicillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Amoxicillin is, however, susceptible to degradation by Beta-lactamases, and therefore, the spectrum of activity does not include organisms which produce these enzymes.

Clavulanic acid is a Beta-lactam, structurally related to the penicillins, which possesses the ability to inactivate a wide range of Beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. In particular, it has good activity against the clinically important plasmid-mediated Beta-lactamases frequently responsible for transferred drug resistance.

PHARMACOLOGY

PHARMACOKINETICS: –

ABSORPTION: – Amoxicillin is stable in the presence of gastric acid, oral absorption is better, presence of food does not interrupt with its absorption.

DISTRIBUTION: – Diffusion of the drug takes place into most body tissues and fluids, but it does not crosses the blood brain barrier and the spinal fluid. It crosses the placenta; small amounts are distributed into breast milk.

INDICATIONS: –

  • Acute bacterial sinusitis (adequately diagnosed)
  • Cystitis
  • Pyelonephritis
  • Cellulitis
  • Animal bites
  • Severe dental abscess with spreading cellulitis.
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