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TYZONE-T INJ


COMPOSITION: CEFOPERAZONE 1000MG & TAZOBACTAM 125MG

PACKING: 1.125GM

Category: .
Description

Pharmacology

Cefoperazone

Pharmacodynamics

Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits Transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporin’s like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis

Pharmacokinetics

Absorption: Orally not well absorbed & should be given parenterally,

Distribution: widely distributed & good CSF penetration,

Metabolism: It is not significantly metabolized inside the body.

Excretion: Excreted mainly through bile & a small portion is excreted in urine. A small amount is seen in breast milk.

Indications

Cefoperazone

  • Meningitis
  • Biliary infections
  • Septicemia
  • Infections in immune compromised patients
  • Urinary tract &genital tract infections
  • Surgical prophylaxis
  • Skin & soft tissue infections
  • Bone & Joint infections
  • Gonorrhea
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