COMPOSITION: CEFOPERAZONE 1000MG & TAZOBACTAM 125MG
Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits Transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporin’s like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis
Absorption: Orally not well absorbed & should be given parenterally,
Distribution: widely distributed & good CSF penetration,
Metabolism: It is not significantly metabolized inside the body.
Excretion: Excreted mainly through bile & a small portion is excreted in urine. A small amount is seen in breast milk.