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OLOZEN


COMPOSITION: OLOPATADINE HYDROCHLORIDE 0.1 % W/V

PACK: 5ML

Category: .
Description

OLOZEN, 0.1% is a sterile ophthalmic solution containing olopatadine, a relatively selective H1-receptor antagonist and inhibitor of histamine release from the mast cell for topical administration to the eyes. Olozen is indicated for the treatment of the signs and symptoms of allergic conjunctivitis. Pharmacology Pharmacokinetics:- 1. Absorption: – Ophthalmic use of olopatadine usually does not produce measurable plasma concentrations. 2. Metabolism: – The mono-desmethyl and the N-oxide metabolites have been detected at low concentrations in the urine. 3. Route of Elimination: – Elimination was predominantly through renal excretion. Indication: – Used to treat allergic conjunctivitis (itching eyes), olopatadine inhibits the release of histamine from mast cells. It is a relatively selective histamine H1 antagonist that inhibits the in vivo and in vitro type 1 immediate hypersensitivity reaction including inhibition of histamine induced effects on human conjunctival epithelial cells.

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