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XYNAC-200 TAB

XYNAC-200 TAB

COMPOSITION:ACECLOFENAC 100MG

PACKING:10×10 TABLETS

Description

ACECLOFENAC

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.

PHARMACOLOGY

PHARMACODYNAMICS:

Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic properties. The mode of action of aceclofenac is largely based on the inhibition to prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins.

PHARMACOKINETICS:

Absorption: – After oral administration, aceclofenac is rapidly and completely absorbed as unchanged drug.

Distribution: – Peak plasma concentrations are reached approximately 1.25 to 3.00 hours following ingestion. Aceclofenac penetrates into the synovial fluid, where the concentrations reach approximately 57% of those in plasma. The volume of distribution is approximately 25 L.

Elimination: – The mean plasma elimination half-life is around 4 hours. Aceclofenac is highly protein- bound (>99%). Aceclofenac circulates mainly as unchanged drug. 4′- hydroxyl-aceclofenac is the main metabolite detected in plasma. Approximately two- thirds of the administered dose is excreted via the urine, mainly as hydroxyl-metabolites.
No changes in the pharmacokinetics of aceclofenac have been detected in the elderly.

INDICATIONS:

  • This medication is a nonsteroidal anti-inflammatory drug (NSAID), prescribed for fever, pain, ankylosing spondylitis and arthritis.
      It blocks the action of a substance in the body (cyclo-oxygenase), which may cause pain, swelling and inflammation. It blocks the action of a substance in the body (cyclo-oxygenase), which may cause pain, swelling and inflammation.
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