For the treatment of sinus and nasal congestion and eustachian tube congestion due to the common cold, allergic rhinitis, or sinusitis.
For vasoconstriction for regional anesthesia.
For hypotensive emergencies during spinal anesthesia.
For the prolongation of spinal anesthesia.
For the treatment of clinically important hypotension in the perioperative setting with neuraxial or general anesthesia.
For the treatment of clinically important hypotension primarily from vasodilation in the setting of anesthesia.
MECHANISM OF ACTION
5-RIZ-D prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. 5-RIZ-D Diphenhydramine is a Histamine-1 Receptor Antagonist. The mechanism of action of diphenhydramine is as a Histamine H1 Receptor Antagonist.Phenylephrine is a direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property.5-RIZ-D Phenylephrine is a post-synaptic alpha-adrenergic receptor agonist that causes vasoconstriction, increases systolic/diastolic pressures, reflex bradycardia, and stroke output.