Description
GAZO-D-75/20 is a fixed-dose combination of Pregabalin and Duloxetine, designed for the effective management of neuropathic pain, fibromyalgia, and associated mood disturbances. The synergistic action of an anticonvulsant (Pregabalin) and an SNRI antidepressant (Duloxetine) provides dual relief—addressing both the pain pathways and underlying psychological distress commonly associated with chronic pain conditions.
Pharmacological Action
Duloxetine (20 mg):
-
-
A serotonin-norepinephrine reuptake inhibitor (SNRI).
-
Enhances descending inhibitory pain pathways.
-
Relieves neuropathic pain and improves associated depression or anxiety.
-
Pregabalin (75 mg):
-
-
Binds to the α2δ subunit of voltage-gated calcium channels in the CNS.
-
Reduces excitatory neurotransmitter release.
-
Provides analgesic, anticonvulsant, and anxiolytic effects.
Indications
GAZO-D-75/20 is indicated for
-
Diabetic peripheral neuropathy
-
Neuropathic pain of various origins
-
Fibromyalgia
-
Chronic musculoskeletal pain
-
Pain associated with depression and anxiety disorders
-
-
