TEXAR-T INJ MANUFACTURERS SUPPLIERS - THIRD PARTY CONTRACT MANUFACTURING
COMPOSITION: CEFTRIAXONE 1000 MG TAZOBACTUM 125 MG
Ceftriaxone interferes with the biosynthesis of the peptidoglycan component of the bacterial cell way by binding to and inactivating penicllin-binding proteins (PBPs). Tazobactam is a penicillanic acid sulfone derivative with β-lactamase inhibitory properties. It enhances the activity of β-lactam antibacterials against β-lactamase-producing bacteria.
Distribution: – Ceftriaxone: 98% bound to plasma proteins; crosses the blood brain barrier. Tazobactam:About 30% bound to plasma proteins; widely distributed to tissues and body fluids.
Excretion: – Ceftriaxone: Elimination half-life is about 8.7 hours; 33-67% removed as unchanged drug. Tazobactam: Removed mainly via kidneys with 80% of an administered dose as unchanged drug