PANTOPRAZOLE SODIUM 40 MG + CINITAPRIDE HYDROGEN TARTRATE 3 MG

APENTRAL-C is a fixed-dose combination that offers dual benefits in the management of acid-peptic disorders. Pantoprazole, a proton pump inhibitor, provides potent and long-lasting gastric acid suppression, while Cinitapride, a prokinetic agent, improves gastrointestinal motility. Together, they ensure comprehensive relief from gastroesophageal reflux disease (GERD), dyspepsia, and related conditions.

Pharmacological Action

• Pantoprazole Sodium (40 mg):

  • Selective proton pump inhibitor (PPI).

  • Irreversibly blocks H⁺/K⁺-ATPase in gastric parietal cells.

  • Reduces gastric acid secretion and promotes mucosal healing.

• Cinitapride Hydrogen Tartrate (3 mg):

  • A prokinetic agent with serotonin (5-HT4 agonist, 5-HT2 antagonist) activity.

  • Enhances gastric emptying and esophageal motility.

  • Reduces reflux episodes and improves postprandial symptoms.

     

    Indications

    APENTRAL-C is indicated for

    • Gastroesophageal Reflux Disease (GERD)

    • Non-ulcer dyspepsia

    • Functional dyspepsia with delayed gastric emptying

    • Peptic ulcer disease (adjunct therapy)

    • Gastritis with reflux symptoms

    • Nausea, bloating, and fullness due to gastric stasis