Description
Rabeprazole Tablet is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough.
The Rabeprazole Tablet requires the use of precaution. You have too consume the tablets in a limited quantity and console the doctor before use. Take the tablets with a glass of water and do not use any other pharma drug within the combination. It is necessary to maintain the diet. This is not recommended for pregnant women, in case it is necessary, consult the doctor. Try to avoid if you are breastfeeding a child. This is not suitable for children below the age of 18 years.
Rabeprazole Tablet may offer some side effects such as loose stools, nausea, abdominal pain, headache, fatty liver, etc. Take it only under external conditions and store it in a cool and dry place.
WORKING MECHANISM OF RABEPRAZOLE TABLET
Mechanism of Action: – Rabeprazole sodium belongs to the class of anti-secretory compounds, the substituted benzimidazole that does not exhibit anticholinergic or H2 histamine antagonist properties, but suppress gastric acid secretion by the specific inhibition of the H+/K+-ATPase enzyme (the acid or proton pump). The effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus. As a weak base, rabeprazole is rapidly absorbed following all doses and is concentrated in the acidic environment of the parietal cells. Rabeprazole is converted to the active sulphenamide form through protonation and it subsequently reacts with the available cysteines on the proton pump.
Anti-secretory Activity: – After oral administration of a 20 mg dose of rabeprazole sodium the onset of the anti-secretory effect occurs within one hour, with the maximum effect occurring within two to four hours. The inhibitory effect of rabeprazole sodium on acid secretion increases slightly with repeated once-daily dosing, achieving steady-state inhibition after three days. When the drug is discontinued, secretory activity normalises over 2 to 3 days.
PHARMACOKINETICS OF RABEPRAZOLE TABLET
The functions of the Rabeprazole Tablet are mentioned below.
- Absorption: – Since rabeprazole is acid-labile, it is administered as a delayed-release tablet so that it can pass through the stomach relatively intact. Once rabeprazole has left the stomach, absorption occurs within 1 hour of administration. The bioavailability is approximately 52%.
- Distribution: – Distributed in tissue, particularly gastric parietal cells.
- Protein Binding: – Very high; approximately 96% bound to human plasma protein.
- Biotransformation: Rabeprazole is extensively metabolized in the liver by the cytochrome P450 enzyme system into 2 main metabolites. These 2 metabolites do not have any significant antisecretory activity.
- Elimination: – Normal renal function: Approximately 1 to 2 hours. Hepatic function impairment: 2 to 6 hours.
INDICATIONS OF RABEPRAZOLE TABLET
The Rabeprazole Tablet prevents the following conditions
- Gastric ulcer (GU)
- Peptic ulcer disease (PUD)
- Maintenance of healing of erosive or ulcerative GERD
- Healing of erosive and ulcerative GERD
- Healing of duodenal ulcers.
- Treatment of symptomatic GERD
- Treatment of pathological hypersecretory conditions (Zollinger-Ellison syndrome)
- Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence
Note- The Rabeprazole Tablet is only for external use.
Storage- Keep the Rabeprazole Tablet in a cool and dry place.
