RYPRAZ TAB

Rabeprazole 20 mg Tablet- is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. The tablet relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. Rabeprazole is widely used in medical practice and is a prescription medication that provides rapid relief from conditions caused by excess stomach acid. It produces a very strong effect by reducing the production of stomach acid. The medication works faster than most other similar medicines.

Arlak Biotech manufactures Rabeprazole tablets under the brand name Rypraz Tab. It is an ISO and GMP-certified company known for producing medicines in various therapeutic segments. The company is also recognized for providing exclusive monopoly rights to its business partners and allows them to market products in their specific territories.

Working Mechanism Of Rabeprazole Tablet

Mechanism of Action: – Rabeprazole sodium belongs to the class of anti-secretory compounds, the substituted benzimidazole that does not exhibit anticholinergic or H2 histamine antagonist properties, but suppress gastric acid secretion by the specific inhibition of the H+/K+-ATPase enzyme (the acid or proton pump). 

The effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus. As a weak base, rabeprazole is rapidly absorbed following all doses and is concentrated in the acidic environment of the parietal cells. Rabeprazole is converted to the active sulphenamide form through protonation and it subsequently reacts with the available cysteines on the proton pump.

Pharmacokinetics Of Rabeprazole Tablet

The functions of the Rabeprazole Tablet are mentioned below.

• Absorption: – Since rabeprazole is acid-labile, it is administered as a delayed-release tablet so that it can pass through the stomach relatively intact. Once rabeprazole has left the stomach, absorption occurs within 1 hour of administration. The bioavailability is approximately 52%.
• Distribution: – Distributed in tissue, particularly gastric parietal cells.
• Protein Binding: – Very high; approximately 96% bound to human plasma protein.
• Biotransformation: Rabeprazole is extensively metabolized in the liver by the cytochrome P450 enzyme system into 2 main metabolites. These 2 metabolites do not have any significant antisecretory activity.
• Elimination: – Normal renal function: Approximately 1 to 2 hours. Hepatic function impairment: 2 to 6 hours.

Side Effects Of Rabeprazole Tablet

Like every medication, Rabeprazole also has some side effects. These effects are mild and temporary when the medication is taken as directed. However, if severe symptoms occur, consult your doctor as soon as possible.  

• Headache
• Diarrhea
• Constipation
• Nausea
• Vomiting
• Flatulence
• Abdominal pain
• Weakness
• Fatigue
• Runny nose
• Dizziness

Precautions For Rabeprazole Tablet

For best results, use this medication with safety. Being mindful of the following aspects helps reduce the unwanted effects. 

• You have to consume the tablets in a limited quantity and consult the doctor before use. 
• Take the tablets with a glass of water and do not use any other pharma drug with it. 
• It is recommended to maintain a balanced diet before consuming these tablets. 
• The tablets are not prescribed for pregnant or breastfeeding women.
• Inform your doctor in advance if you have severe liver disease, osteoporosis and low magnesium levels.
• Take immediate medical support if you experience severe diarrhea and joint pain. 

Indications Of Rabeprazole Tablet

The Rabeprazole Tablet prevents the following conditions

• Gastric ulcer (GU)
• Peptic ulcer disease (PUD)
• Maintenance of healing of erosive or ulcerative GERD
• Healing of erosive and ulcerative GERD
• Healing of duodenal ulcers.
• Treatment of symptomatic GERD
• Treatment of pathological hypersecretory conditions (Zollinger-Ellison syndrome)
• Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence.

Storage- Keep the Rabeprazole Tablet in a cool and dry place.

Frequently Asked Questions

Q1- Are Rabeprazole tablets better than omeprazole tablets?

A- Rabeprazole is generally considered as a fact-acting and more effective medication than omeprazole.

Q2- Who should not use Rabeprazole tablets?

A- Individuals who are allergic to Rabeprazole or other PPIs, liver issues or active prolactinoma should not use the tablets. 

Q3- Do Rabeprazole tablets provide relief from acid reflux at night?

A- Rabeprazole is highly effective at night time due to its quick action and 24 hour acid suppression.

Q4- Are Rabeprazole tablets safe for children? 

A- Rabeprazole tablets are generally considered safe for children older than 12 years.

Q5- Can I stop taking Rabeprazole tablets once I start feeling better?

A- Stopping the medication too quickly can increase stomach acid. You should follow the complete course.

Q6- Can Rabeprazole tablets cause long-term issues?

A- Long-term use of the tablets can cause serious infections due to lower stomach acid levels.

Q7- Should I take the Rabeprazole tablets before a meal?

A- It is recommended to take the tablets about 30-60 minutes before a meal.