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Glimepiride, Pioglitazone & Metformin Hydrochloride (ER) Tablets – A combination of three antidiabetic medicines, Glimepiride, Pioglitazone, and Metformin are used in the treatment of Type 2 diabetes mellitus. These medicines help in controlling blood sugar levels. Available with the brand name ZULIP-GP1, these tablets are manufactured and supplied by the Best Glimepiride, Pioglitazone & Metformin Hydrochloride Tablet Manufacturer, Arlak Biotech.

Mechanism of Action

When one or dual therapy is ineffective, Glimepiride, Pioglitazone & Metformin work through various ways to provide better control of blood sugar levels.

Glimepiride is a sulfonylurea that works by lowering blood glucose by increasing the insulin amount that the pancreas releases.

Pioglitazone is a thiazolidinedione that acts by reducing the amount of glucose that the liver produces while making the tissues more sensitive to the actions of insulin.

Metformin is a biguanide that functions by reducing the liver’s ability to produce glucose, slowing the intestine’s ability to absorb glucose, and increasing the sensitivity of the body to insulin.

General Instructions

Medicinal treatment of Type 2 diabetes mellitus requires complete caution. Thus, while taking Glimepiride, Pioglitazone & Metformin Hydrochloride (ER) Tablets, keep the following general instructions in consideration:

  1. Take Glimepiride, Pioglitazone & Metformin Hydrochloride (ER) Tablets with a meal to decrease the chances of having an upset or disturbed stomach.
  2. Do not consume these tablets if you are allergic to Glimepiride, Pioglitazone, Metformin, or any of the other contents present in this medicine.
  3. If you experience any hypoglycemic symptoms such as cool pale skin, anxiety, cold sweats, etc., intake some fruit juice or sugary food to calm them.
  4. When combined with other anti-diabetic medicines, if a meal is skipped or delayed, or if an alcoholic beverage is consumed, Glimepiride, Pioglitazone & Metformin Hydrochloride (ER) Tablets may result in hypoglycemia (low blood sugar level). Thus, it is necessary to take care of them with complete caution.

When to Not Take Glimepiride, Pioglitazone & Metformin Hydrochloride (ER) Tablets

Glimepiride, Pioglitazone & Metformin Hydrochloride (ER) Tablets should not be taken without consulting the doctor in the following health conditions:

  1. Type 1 Diabetes
  2. Vitamin B12 Deficiency
  3. Bladder Cancer
  4. Anemia
  5. Edema
  6. Premenopausal Anovulation
  7. congestive Heart Failure
  8. Kidney or Liver Diseases
  9. Pregnancy or Breastfeeding

Side Effects

Glimepiride, Pioglitazone & Metformin Hydrochloride (ER) Tablets may result in common side effects. These adverse effects can range from mild to moderate.  Following are the common side effects associated with this medication:

  1. Nausea
  2. Diarrhea
  3. Vomiting
  4. Stomach Ache
  5. Headache
  6. Dizziness

In case you encounter any severity in these side effects or they don’t leave the body, consult the doctor.

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