Description
BRAND NAME :- 5-RIZ -D TAB
COMPOSITION :- PARACETAMOL 500 mg + PHENYLPHERINE 5 mg + CAFFIENE 30 mg + DIPHENHYDRAMINE 25 mg + HYDROCHLORIDE
PACKING :- 10 X 10 BLISTER
MEDICATION USED FOR
5-RIZ -D are used for the relief of the symptoms of colds and flu, including headache, feverishness (high temperature), nasal and sinus congestion and its associated pressure and pain, catarrh, aches and pains.This is a combination of four medicines: Caffeine, Diphenhydramine, Paracetamol / Acetaminophen, and Phenylephrine which relieve common cold symptoms. Diphenhydramine is an antiallergic which relieves allergy symptoms like runny nose, watery eyes and sneezing. Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It blocks the release of certain chemical messengers in the brain that are responsible for pain and fever. Caffeine increases the effectiveness of paracetamol and decreases sleepiness caused by diphenhydramine. Phenylephrine is a decongestant which narrows the small blood vessels providing temporary relief from congestion or stuffiness in the nose.
INDICATIONS
5-RIZ-D Tablets indicates :
For the treatment of internal and external symptoms of hemorrhoids.
For the treatment of sinus and nasal congestion and eustachian tube congestion due to the common cold, allergic rhinitis, or sinusitis.
For vasoconstriction for regional anesthesia.
For hypotensive emergencies during spinal anesthesia.
For the prolongation of spinal anesthesia.
For the treatment of clinically important hypotension in the perioperative setting with neuraxial or general anesthesia.
For the treatment of clinically important hypotension primarily from vasodilation in the setting of anesthesia.
MECHANISM OF ACTION
5-RIZ-D prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. 5-RIZ-D Diphenhydramine is a Histamine-1 Receptor Antagonist. The mechanism of action of diphenhydramine is as a Histamine H1 Receptor Antagonist.Phenylephrine is a direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property.5-RIZ-D Phenylephrine is a post-synaptic alpha-adrenergic receptor agonist that causes vasoconstriction, increases systolic/diastolic pressures, reflex bradycardia, and stroke output.
