CINNARIZINE 20 MG & DOMPERIDONE 15 MG TABLETS

PHARMACOLOGY
PHARMACODYNAMICS:

Cinnarizine Has Ca Channel Blocking Activity Selective For Arterial Smooth Muscles. It Has Some Antihistamine Activity. Cinnarizine Acts As A Labyrinthine Sedative. It Also Improves Microcirculation By Reducing Ischemia-induced Blood Viscosity. Domperidone Is a Peripheral Dopamine-receptor Blocker. It Increases both the esophageal Peristalsis and the Lower esophageal Sphincter Pressure. It also Increases Gastric Motility and Peristalsis, and Enhances Gastro duodenal Coordination, Thus Facilitating Gastric Emptying and Decreasing Small Bowel Transit Time.

PHARMACOKINETICS:

Cinnarizine has Ca channel blocking activity selective for arterial smooth muscles. It has some antihistamine activity. Cinnarizine acts as a labyrinthine sedative. It also improves microcirculation by reducing ischemia-induced blood viscosity. Domperidone is a peripheral dopamine-receptor blocker. It increases both the esophageal peristalsis and the lower esophageal sphincter pressure. It also increases gastric motility and peristalsis, and enhances gastroduodenal coordination, thus facilitating gastric emptying and decreasing small bowel transit time.

INDICATIONS:

• Vestibular disorders
• Prophylaxis and control of Motion sickness
• Nausea and vomiting of varied aetiology