Description
The TARSNIL A TAB belong to the group of anti-malaria drugs. This helps treat the health issues caused by mosquito bites and malaria. This beneficial pharmaceutical dose responsibly cures the condition of the plasmodium parasite, a disease transmitted by the bite of Anopheles mosquitoes.
The mosquitoes transmit the symptom of plasmodium within 10 days of the bite. Slowly the body loses its strength and causes a poor. This radially develops the problem and makes them extremely sick. The symptoms include a reduction in red blood cells, liver cell infection, high fever, chills, vomiting, indigestion, anemia, bloody stools, and more.
Using ARTEMETHER 80 MG & LUMEFANTRINE 480 MG TABLETS will protect against the harmful appearance of malaria symptoms. It reduces the growth of the plasmodium parasite, increases the red blood cells, and improves the functioning of the liver. It is a helpful medicine that treats various issues caused by malaria.
Regular consumption of ARTEMETHER 80 MG & LUMEFANTRINE 480 MG TABLETS requires the use of precaution. You have to take the medicine as offered by the healthcare experts. Do not consume alcohol, and take the medicine at a responsible time. This is not suitable for pregnant women. You may suffer from some side effects such as loose stools, abdominal pain, fatigue, etc. Contact the professional for more knowledge.
USES OF ARTEMETHER 80 MG & LUMEFANTRINE 480 MG TABLETS
Here are the useful benefits of the ARTEMETHER 80 MG & LUMEFANTRINE 480 MG TABLETS.
- It is indicated in the treatment of uncomplicated falciparum malaria which is resistant to other antimalarials.
- The product delivers the benefit of an increase in red blood cells.
- It improves the function of liver cells and provides a protective improvement in health.
- The fever, chills, and lack of energy are balanced with the use of these tablets.
PHARMACOLOGY OF ARTEMETHER 80 MG & LUMEFANTRINE 480 MG TABLETS
A.) PHARMACODYNAMICS:
Artemether is a semi-synthetic derivative of artemisinin. It is active against all of the erythrocytic stages of parasites, including transmissible gametocytes, resulting in a rapid clinical benefit and decreased transmission of malaria. The Endoperoxide Bridge in the artesunate molecule appears to interact with heme in the parasite and inhibits protein synthesis of the parasite which results in the lysis of the parasite.
PHARMACOKINETICS of ARTEMETHER 80 MG & LUMEFANTRINE 480 MG TABLETS
- Absorption: – Artemether is absorbed with peak plasma concentrations reached about 2 hours after dosing. Absorption of lumefantrine, a highly lipophilic compound, starts after a lag time of up to 2 hours, with peak plasma concentrations about 6 to 8 hours after administration.
- Distribution: – Artemether and lumefantrine are both highly bound to human serum proteins in vitro (95.4% and 99.7%, respectively). Dihydroartemisinin is also bound to human serum proteins (47% to 76%).
- Protein Binding: – The protein binding to human plasma proteins is linear.
- Metabolism: – The metabolism of artemether was catalyzed predominantly by CYP3A4/5. Dihydroartemisinin (DHA) is an active metabolite of artemether. The metabolism of artemether was also catalyzed to a lesser extent by CYP2B6, CYP2C9 and CYP2C19.In human liver microsomes and in recombinant CYP450 enzymes, lumefantrine was metabolized mainly by CYP3A4 to dibutyl-lumefantrine. The systemic exposure to the metabolite dibutyl-lumefantrine was less than 1% of the exposure to the parent compound.
- Elimination: – Artemether and DHA are cleared from plasma with an elimination half-life of about 2 hours. Lumefantrine is eliminated more slowly, with an elimination half-life of 3-6 days.
Note- The ARTEMETHER 80 MG & LUMEFANTRINE 480 MG TABLETS is for external use.
Storage- Keep ARTEMETHER 80 MG & LUMEFANTRINE 480 MG TABLETS in a cool and dry place.
