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Levocetirizine About Levocetirizine A third-generation non-sedative H1 antagonist, Antihistamine. Mechanism of Action of Levocetirizine This active enantiomer of cetrizine is a potent, nonsedative and selective H1 receptor antagonist. It antagonizes the allergic symptoms produced by histamines like runny nose, cold, cough etc. It also inhibit eotaxin-induced eosinophil TEM through both dermal and lung micro vascular endothelial cells. So inhibit eosinophil chemotaxis and also inflammation caused by it. Pharmacokinets of Levocetirizine Absorption- Well absorbed after oral administration. Distribution-Widely distributed in the body.90% bound to the plasma proteins. Metabolism- Metabolized in the liver to its metabolites. Excretion- Excreted via urine and feces. Side Effects of Levocetirizine 1. Headache 2. Abdominal pain 3. Dry mouth 4. Fatigue 5. Pharyngitis 6. Sleepiness 7. Asthenia 8. Rhinitis causing a blocked or runny nose 9. Migraine Contra-indications of Levocetirizine 1. Allergy to drug or other medicines that contain piperazine derivatives 2. Hereditary galactose intolerance 3. Hereditary Lapp lactase deficiency 4. Inherited glucose-galactose malabsorption 5. Severely decreased kidney function Special Precautions while taking Levocetirizine 1. Decreased kidney function 2. Avoid alcohol or any work which require mental alertness like driving and machine operation during treatment. Montelukast About Montelukast Leukotriene(CysLT1) Receptor Antagonist, Antiinflammatory,antiasthma. Mechanism of Action of Montelukast Montelukast is competitively and selectively antagonizes CysLT1 receptor (leukotrienes receptor) mediated Bronchoconstriction.Montelukast inhibits physiologic actions of LTD 4 at the CysLT1 receptor without any agonist activity. Pharmacokinets of Montelukast Absorption: Montelukast is rapidly absorbed after oral administration and its bioavailability is about 60 – 70%. Distribution: It is minimally distributed to the tissues in protein bound form (99%) Metabolism: It is extensively metabolised in the liver. Excretion: Montelukast is excreted in the faeces. Side Effects of Montelukast 1.Headache 2.Dizziness 3.Nasal congestion 4.Sore throat 5.Abdominal pain 6.Fatigue 7.Asthenia 8.Cough 9.Influenza 10.Rash 11.Fever 12.Trauma 13.Trauma 14.Dyspepsia Contra-indications of Montelukast 1.Hypersensitivity to Montelukast 2.Acute asthmatic attacks Ambroxol About Ambroxol Active N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver. Mechanism of Action of Ambroxol Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties. Side Effects of Ambroxol 1. Rhinorrhoea 2. Lacrimations 3. Allergic reactions 4. Gastric irritation. Contra-indications of Ambroxol Hypersensitivity to the Ambroxol hydrochloride or Bromhexine. Special Precautions while taking Ambroxol 1.Hepatic impairment 2.Renal impairment 3.Gastric and duodenal ulcer 4.Convulsive disorders
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