SODIUM VALPROATE AND VALPROIC ACID CONTROLLED RELEASE TABLET 500 MG

Description

VALPOSET 500 TAB is a combination of sodium Valproate and Valproic Acid, with each contribution of a total of 500mg of active ingredients. The formulation of VALPOSET 500 is mainly used for managing various types of epilepsy, bipolar disorder, and for the prevention of migraine headaches. It is a controlled-release tablet. 

VALPOSET 500 is a SODIUM VALPROATE AND VALPROIC ACID under the brand name of VALPOSET 500, manufactured by Arlak Biotech. Arlak Biotech is India’s leading Franchise Company with a 2500+ product range and 16 Divisions. The company is well established in the Pharma industry and is trusted for its superior quality. Arlak Biotech operates PAN India by offering its Pharma Franchise business opportunity 

Composition and Mechanism of Action 

VALPOSET 500 is formulated with two active components: 

1. Sodium Valproate: It is a salt form of valproic acid; it releases valproate ions upon dissociating in the gastrointestinal tract  
2. Valproic acid: It is a derivative of a fatty acid. Valproic acid enhances the brain’s inhibitory neurotransmitter gamma-aminobutyric acid levels, stabilizing neuronal activity. 
3. The controlled-release formulation ensures a steady release of medication, maintaining consistent blood levels and reducing dosing frequency. 

Uses and Benefits  

VALPOSET 500 is indicated for:​ 

1. Epilepsy: Effective against various seizure types, including generalized tonic-clonic, absence, myoclonic, and partial seizures.​
2. Bipolar Disorder: Used to manage manic episodes and as maintenance therapy to prevent mood swings.
3. Migraine Prophylaxis: Helps in reducing the frequency and severity of migraine attacks. 

Dosage and Administration  

1. For initial uses, it starts as 600mg per day.
2. The dose may be increased by 200m in every three days until optimal control is achieved.
3. Maintenance dose the maintenance dose depends on the individual response and tolerability; the dose ranges between 1000mg to 2000 mg.
4. The Valposet 500 tablet should be swallowed whole with water and not crushed or chewed. 

Precautions  

1. It is very important to do regular monitoring due to the risk of hepatotoxicity during the first six months of therapy.
2. The patient should be aware of the symptoms, like abdominal pain, nausea, and vomiting, which require immediate medical attention.
3. Valproate should not be consumed during pregnancy as it causes a risk of birth defects and developmental disorders.
4. Contraindicated in individuals with known hypersensitivity to valproate or any component of the formulation. 

Potential side effects 

Common side effects may include: 

1. Nausea and vomiting​
2. Drowsiness or dizziness
3. Tremors​
4. Weight gain​
5. Hair loss​ 

Possible Side Effects of Tablets 

1. Signs of liver damage: yellowing of the skin or eyes, dark urine, severe fatigue.
2. Pancreatitis: severe abdominal pain, persistent nausea.
3. Unusual bruising or bleeding.
4. Mood changes, depression, or suicidal thoughts​